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Archives Of Pathology & Laboratory Medicine

Category: Pathology

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  • Synopsis: Liver Biopsy Interpretation, 4th ed, by Peter J. Scheuer, 304 pp, 225 illus. ... Donald T. Forman, PhD Chapel Hill, NC Illustrated Textbook of Clinical Chemistry , by William J. Marshall, 326 pp, with illus, $12 (soft cover), London, England, Gower ...

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(Archives of Pathology and Laboratory Medicine[TA])

  • Zika and the Blood Supply: A Work in Progress. [Journal Article]
  • AP Arch Pathol Lab Med 2016 Oct 27
  • Katz LM, Rossmann SN
  • Zika virus can be transmitted by transfusion, but the harm caused to recipients is not clear in most cases. It is very likely that the virus could also be transmitted by transplanted organs. Sensitiv.

Zika virus can be transmitted by transfusion, but the harm caused to recipients is not clear in most cases. It is very likely that the virus could also be transmitted by transplanted organs. Sensitivity to the risk from transfusion is elevated by consideration of possible severe neurologic damage in fetuses. Strategies for dealing with transfusion risk vary with the presence of Zika in the region. In nonendemic areas, risks can be reduced by excluding donors who have exposure through travel or sexual contact with someone at risk. In both endemic and nonendemic areas, the risk can be further reduced by nucleic acid testing of donors, or pathogen reduction of platelet and plasma products. The real risk to the population depends on the frequency of infection as well as the efficacy of these interventions. The interventions chosen will depend on the risk assessment for any situation; in the United States at this time, a combination of travel deferrals, testing, and, to a lesser extent, pathogen reduction is being used, but universal testing of US blood donors under investigational use has been mandated by the US Food and Drug Administration, beginning with states most at risk of local transmission. Canada is largely using travel deferrals. A precautionary approach may be taken; however, a formal decision-making framework has been suggested. The situation globally is clearly very fluid, as the epidemic continues to spread and we continue to learn how to best protect recipients of blood and transplants.

  • Pathologist Effort in the Performance of Fetal, Perinatal, and Pediatric Autopsies: A Survey of Practice. [Journal Article]
  • AP Arch Pathol Lab Med 2016 Oct 27
  • Pacheco MC, Reed RC
  • CONCLUSIONS: -Fetal, perinatal, and pediatric autopsies are time intensive and frequently complex. They have high clinical value, guiding risk assessment and reproductive decision making by families. Understanding the time contribution by pathologists allows departments and hospitals to predict staffing.
  • Updates on Precancerous Lesions of the Biliary Tract: Biliary Precancerous Lesion. [Journal Article]
  • AP Arch Pathol Lab Med 2016; 140(11):1285-1289
  • Ainechi S, Lee H
  • Precursor lesions of invasive adenocarcinoma of the bile duct (cholangiocarcinoma) have been increasingly recognized during the past decade because of the results of multiple studies on the carcinoge.

Precursor lesions of invasive adenocarcinoma of the bile duct (cholangiocarcinoma) have been increasingly recognized during the past decade because of the results of multiple studies on the carcinogenesis of cholangiocarcinoma, technologic advancements in diagnostic imaging modalities, and an increase in the volume of elective procedures. The two main precursor lesions of cholangiocarcinoma that have evolved are biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. These lesions demonstrate histomorphologic similarities to pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm of the pancreas, respectively, whereas mechanisms of carcinogenesis and risk of progressive disease appear distinct. An enhanced understanding of the clinical presentation and pathologic features of precursor lesions of the biliary tract and use of the correct terminology will facilitate efficient communication between surgeons, oncologists, and pathologists and improve quality of patient care.

  • Mitogen-Activated Protein Kinase Signaling Pathway in Cutaneous Melanoma: An Updated Review. [Journal Article]
  • AP Arch Pathol Lab Med 2016; 140(11):1290-1296
  • Acosta AM, Kadkol SS
  • The mitogen-activated protein kinase (MAPK) signaling pathway is a cascade of protein kinases that act in a sequential and predominantly linear fashion, albeit displaying some cross talk with other s.

The mitogen-activated protein kinase (MAPK) signaling pathway is a cascade of protein kinases that act in a sequential and predominantly linear fashion, albeit displaying some cross talk with other signaling cascades. Mutations in proteins integral to the MAPK signaling pathway are present in more than 50% of cutaneous melanomas. The most frequently mutated protein is v-raf murine sarcoma viral oncogene homolog B (BRAF), followed by neuroblastoma Ras viral oncogene homolog (NRAS). Recently, the development of targeted drugs for the treatment of BRAF-mutant melanoma has led to the widespread implementation of molecular assays for the detection of specific BRAF mutations. There have been some attempts to standardize testing of BRAF mutations, but this has not been achieved so far. Here we provide an updated review on the role of the MAPK signaling pathway in the pathogenesis of cutaneous melanoma, focusing on several different BRAF mutations and their diagnostic and therapeutic implications.




The Archives of Pathology - Laboratory Medicine

Seventy-five Years and Counting

The Archives of Pathology & Laboratory Medicine with this issue celebrates its 75th year of publication. During these 75 years, the journal has evolved from a publication with a narrow focus on anatomical and experimental pathology and a limited circulation to a journal covering the entire field of pathology and laboratory medicine with an international circulation. The journal started in 1926 as one of the Archives specialty journals of the American Medical Association (AMA) and today is published as the official journal of the College of American Pathologists (CAP) in association with the AMA. All CAP members receive the Archives of Pathology & Laboratory Medicine as a membership benefit. This distribution, plus the additional subscription circulation to individuals and libraries, gives the journal an average monthly circulation of 16 000, the largest of any peer-reviewed journal covering the entire field of pathology and laboratory medicine.

This article will briefly review and celebrate the history of the ARCHIVES during its first three quarters of a century.

The founding editor of the ARCHIVES, Ludvig Hektoen, MD, of Chicago, Ill, was a beloved and nationally recognized leader both in the field of pathology and in medical research (Figure)[1-3] His research interests were broad and included the pathology of infectious diseases, immunology, and forensic pathology. He served as chair of the Departments of Pathology at both the Rush Medical College in Chicago and the University of Chicago and held many other leadership positions in medicine and pathology, both locally and nationally. Dr Hektoen was the recipient of numerous honors during his career, including membership in the National Academy of Sciences. He and a small editorial board of 5 distinguished American pathologists led the ARCHIVES during the first quarter of a century of its existence.

The editors following Hektoen included Granville Bennett, MD, chair of the Department of Pathology at the University of Illinois, 1950-1954; Paul R. Cannon, MD, chair of the Department of Pathology at the University of Chicago, 1954-1963; D. Murray Angevine, MD, chair of the Department of Pathology at the University of Wisconsin at Madison and then Associate Director for Research at the Armed Forces Institute of Pathology in Washington, DC, 1964-1973; Kenneth M. Brinkhous, MD, chair of the Department of Pathology at the University of North Carolina at Chapel Hill, 1974-1983; and William W. McLendon, MD, vice-chair of the Department of Pathology and Laboratory Medicine at the University of North Carolina at Chapel Hill 1984-1997. Kenneth D. McClatchey, DDS, MD, chair of the Department of Pathology at Loyola University Medical Center in Maywood, Ill, has served as the seventh editor of the ARCHIVES since 1998.

Over the years, the ARCHIVES has undergone various changes in direction and affiliation, while maintaining its association with the AMA and its commitment to the advancement of the field of pathology and laboratory medicine. The ARCHIVES began in 1926 as the Archives of Pathology and Laboratory Medicine. This was a farsighted title for the time, but for unknown reasons the "and Laboratory Medicine" was dropped in 1928. With the 50th anniversary issue in January 1976, the title returned to the original Archives of Pathology & Laboratory Medicine.[4] This change in name reflected the reality of the practice of pathology and laboratory medicine in the last quarter of the 20th century. As well, it emphasized the fact that pathologists are physicians with a commitment to medicine. As a senior pathology resident at the time noted, "for the first time in years, the words `pathology' and `medicine' shared the masthead of a major pathology journal."[5]

In 1956, the ARCHIVES became the official journal of the American Society for Experimental Pathology. This relationship continued until 1970, when the American Journal of Pathology (founded in 1925) became the official journal of the American Society for Experimental Pathology and the American Association of Pathologists and Bacteriologists. The 2 societies later merged and in 1993 became the current American Society for Investigative Pathology.

In 1984, the CAP joined the AMA in sponsorship of the ARCHIVES.[6] Under this agreement, the AMA remained the publisher, while the CAP contributed significant financial support and provided the journal as a benefit to all of its members.

Peer-reviewed articles from the various CAP laboratory improvement programs soon began to appear in the ARCHIVES. These articles provide pathologists and others direct access to the data from these unique studies. Another major change occurred in 1988 with the publication of the first papers from a CAP conference.[7] These conferences were established to review advancing knowledge in specific areas of pathology and laboratory medicine. The proceedings of the first 12 CAP conferences were published in book form, a process that was time consuming and provided limited circulation. With the publication in the ARCHIVES of CAP Conference XIII on "The Evaluation of Proficiency Testing Results for Quantitative Methods in Relation to Clinical Usefulness," the peer-reviewed conference papers were indexed in the medical literature and were widely available in a timely fashion. Since that time, selected peer-reviewed papers from some 20 CAP conferences have appeared in the ARCHIVES.

The next major publishing development came in 1995, when the ARCHIVES became the official journal of the CAP,[8] which assumed full fiscal and editorial responsibility for the ARCHIVES, while the AMA retained ownership of the title. The college contracted with Allen Press in Lawrence, Kan, for publication of the journal, and this relationship has continued to be mutually beneficial.

In conclusion, as the ARCHIVES celebrates its diamond anniversary, the journal has an exciting mixture of 75 years of publication tradition with continuing innovation that assures its ongoing vitality. The ARCHIVES retains its status as a member of the AMA scientific publication group, which includes JAMA and the other 9 AMA specialty journals. The editor of the ARCHIVES continues to serve as a member of the JAMA Editorial Board and as one of the AMA specialty editors. Furthermore, the ARCHIVES remains committed to its traditional mission of providing pathologists and their colleagues with timely and reliable information to facilitate their provision of high-quality and innovative pathology and laboratory services to physicians and patients.

Under the dynamic leadership of the current editor, Dr Kenneth D. McClatchey, the ARCHIVES has accelerated the effort to provide enhanced benefits for authors and readers. The depth and breadth of the topics covered in a typical issue have continued to improve and expand. Color illustrations routinely appear on the cover, and the publishing of color figures is available to all authors at no additional cost. Residents have been brought into the publication process with the institution of the Residents' Page, where residents have the opportunity to present their cases for publication. An International Advisory Committee with 8 outstanding pathologists from around the world has been established in recognition of the global nature of the practice of medicine and of pathology. In response to the rapidly expanding field of electronic publication, the ARCHIVES now offers full text and illustration retrieval at the CAP Internet Web site at www.cap.org.

All those associated with the Archives of Pathology & Laboratory Medicine--authors, editors, editorial board members, reviewers, editorial and publication staffs, and the sponsoring professional organizations--can take pride in its successes on this 75th anniversary and can look forward with confidence to its centennial celebration in 2026.

[1.] Fishbein M. Ludvig Hektoen: a biography and an appreciation. Arch Pathol. 1938;26:1-31.

[2.] Gruhn JG, Steigmann F Ludvig Hektoen, 1863-1951: founding editor of the Archives of Pathology and Laboratory Medicine. Arch Pathol Lab Med. 1993;117: 748-753.

[3.] Wissler RW. A trip through time to visit four scholarly pathologists I have known: first four editors of the Archives of Pathology and Laboratory Medicine. Arch Pathol lab Med. 1993;117:743-747.

[4.] Brinkhous KM, McLendon WW. The Archives of Pathology and Laboratory Medicine. Arch Pathol Lab Med. 1976;100:1-2.

[5.] Raff LJ. View of the young pathologist. Pathologist. 1983;37:125-128.

[6.] McLendon WW. The Archives of Pathology and Laboratory Medicine: a new beginning. Arch Pathol Lab Med. 1984;108:13-14.

[7.] Langdell RD. The College of American Pathologists Conferences. Arch Pathol Lab Med. 1988;112:319.

[8.] McLendon WW. The Archives of Pathology and laboratory Medicine, the American Medical Association, and the College of American Pathologist: a journal in transition. Arch Pathol tab Med. 1995;119:13-15.

Accepted for publication July 18, 2000.

From the Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.

Reprints not available from the author.



Welcome to UNC Pathology - Laboratory Medicine

Welcome to UNC Pathology & Laboratory Medicine Clinical Services and Laboratories

The McLendon Clinical Laboratories (MCL) provide clinical services in anatomic pathology and laboratory medicine to UNC Hospitals. The MCL web site includes the available clinical services and laboratory tests, test forms and requisitions, test specifications, and the MCL directory .

Departmental Information and Directories

Directories of our faculty members with linked biosketches, departmental leadership. and administrative staff are online. Also online are recent annual reports. a history of the Department, and a photographic archive of our faculty, trainees, and graduate students.

Clinical Training Programs

Our Residency Program in Pathology at UNC Hospitals is a four-year program in anatomic and clinical pathology. We offer fellowships in clinical chemistry, cytopathology, forensic pathology, hematopathology, immunology, laboratory genetics & genomics, microbiology, molecular genetic pathology, renal pathology, surgical pathology, and transfusion medicine.

Doctoral and Post-doctoral Studies

Our Graduate Program in Pathobiology and Translational Science offers a Ph.D. degree in experimental pathology and is closely aligned with specialized graduate training certificate programs. We also offer post-doctoral fellowships in research and in four clinical laboratories.

Research Services and Core Laboratories Seminars and Continuing Medical Education (CME)

Grand Rounds is a weekly CME seminar series scheduled during the fall and spring semesters. The Pathobiology & Translational Science Seminar Series runs biweekly during the spring semester. Our 2016 Annual CME Symposium was April 9 and focused on genitourinary pathology. Our 2016 Annual Research Symposium will be October 13 in Bondurant Hall.



Archives of pathology - laboratory medicine Journal Impact - Description - ResearchGate - Impact Rankings ( 2014, 2015 and 2016 )

Archives of pathology & laboratory medicine (ARCH PATHOL LAB MED)

Publisher: American Medical Association; College of American Pathologists, College of American Pathologists

Journal description

The Archives of Pathology & Laboratory Medicine is the official journal of the College of American Pathologists. It publishes original, peer-reviewed articles for pathologists and clinical laboratory scientists. This information is intended to help laboratorians keep abreast of the ever-increasing knowledge base necessary to the successful practice of pathology and laboratory medicine. The journal actively pursues articles that focus on new and/or complex technologies/disciplines, such as molecular pathology, cytogenetics, HLA, cytometry, and the science of medical laboratory management.

Journal Impact: 2.52*

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

Journal impact history

2016 Journal impact

Article: Prevalence of Traditional and Reverse-Algorithm Syphilis Screening in Laboratory Practice: A Survey of Participants in the College of American Pathologists Syphilis Serology Proficiency Testing Program

[Show abstract] [Hide abstract] ABSTRACT: Context: -Syphilis serology screening in laboratory practice is evolving. Traditionally, the syphilis screening algorithm begins with a nontreponemal immunoassay, which is manually performed by a laboratory technologist. In contrast, the reverse algorithm begins with a treponemal immunoassay, which can be automated. The Centers for Disease Control and Prevention has recognized both approaches, but little is known about the current state of laboratory practice, which could impact test utilization and interpretation. Objective: -To assess the current state of laboratory practice for syphilis serologic screening. Design: -In August 2015, a voluntary questionnaire was sent to the 2360 laboratories that subscribe to the College of American Pathologists syphilis serology proficiency survey. Results: -Of the laboratories surveyed, 98% (2316 of 2360) returned the questionnaire, and about 83% (1911 of 2316) responded to at least some questions. Twenty-eight percent (378 of 1364) reported revision of their syphilis screening algorithm within the past 2 years, and 9% (170 of 1905) of laboratories anticipated changing their screening algorithm in the coming year. Sixty-three percent (1205 of 1911) reported using the traditional algorithm, 16% (304 of 1911) reported using the reverse algorithm, and 2.5% (47 of 1911) reported using both algorithms, whereas 9% (169 of 1911) reported not performing a reflex confirmation test. Of those performing the reverse algorithm, 74% (282 of 380) implemented a new testing platform when introducing the new algorithm. Conclusion: -The majority of laboratories still perform the traditional algorithm, but a significant minority have implemented the reverse-screening algorithm. Although the nontreponemal immunologic response typically wanes after cure and becomes undetectable, treponemal immunoassays typically remain positive for life, and it is important for laboratorians and clinicians to consider these assay differences when implementing, using, and interpreting serologic syphilis screening algorithms.

Article · Oct 2016 · Archives of pathology & laboratory medicine

Article: CDH17 Is a More Sensitive Marker for Gastric Adenocarcinoma Than CK20 and CDX2

[Show abstract] [Hide abstract] ABSTRACT: Context: -CDH17, which is expressed in the intestinal epithelium, is a novel oncogene involved in tumor invasion and metastasis. A panel consisting of cytokeratin (CK) 7, CD20, and CDX2 antibodies is typically used to diagnose gastrointestinal adenocarcinomas. However, studies have shown that CDH17 is a highly specific marker for gastrointestinal adenocarcinoma and may be important in clinical diagnosis. Objective: -To evaluate the sensitivity and specificity of CDH17, CK20, and CDX2 antibodies in neoplastic tissues, with emphasis on colon, stomach, and esophageal gastrointestinal lineage. Design: -Immunohistochemistry was performed with CDH17, CK20, and CDX2 antibodies on formalin-fixed, paraffin-embedded tissue microarrays from normal (n = 26) and neoplastic (n = 884) tissues. Results: -CDH17 immunostaining was positive in 97.3% (145 of 149) of colon adenocarcinomas, whereas CK20 and CDX2 stained positively in 88.6% (132 of 149) and 93.3% (139 of 149), respectively. In metastatic colon cancers, CDH17, CK20, and CDX2 positive staining was observed in 90.6% (29 of 32), 59.4% (19 of 32), and 81.3% (26 of 32) of cases, respectively. In stomach adenocarcinomas, CDH17 positively stained 64.0% (112 of 175) of tissues, compared to CK20 and CDX2, where staining was observed in only 24.6% (43 of 175) and 46.9% (82 of 175), respectively. In esophageal adenocarcinomas, CDH17, CK20, and CDX2 stained 38.7% (12 of 31), 25.8% (8 of 31), and 29% (9 of 31) of specimens, respectively. Low or no expression was observed in other neoplastic tissues, except pancreatic cancers, where CDH17 displayed higher expression than CK20 and CDX2. Conclusions: -CDH17 is a specific and more sensitive marker in the gastrointestinal tract than CK20 and CDX2. CDH17 may be especially valuable when gastrointestinal tumors are suspected in cancers of unknown primary.

Article · Oct 2016 · Archives of pathology & laboratory medicine

Article: Challenges of Frozen Section in Thoracic Pathology: Lepidic Lesions, Limited Resections, and Margins

[Show abstract] [Hide abstract] ABSTRACT: Context: -The use of frozen section in thoracic pathology includes assessment of peripheral lung lesions with lepidic pattern, with greater emphasis on evaluating lung-sparing resections and margin assessment. Objective: -To review pitfalls of frozen section in thoracic pathology; in this setting, reduction of false-positive and false-negative diagnosis in lesion identification and margin assessment is critical. Data sources: -PubMed search of frozen section lung pathology yielded specific references related to the use of frozen section in the identification of lepidic lesions and the clinical recommendation for margin distance. Conclusions: -Frozen section diagnosis is overall accurate in assessment of lepidic lesions. Pitfalls include rare benign mimickers and more common reactive lesions. Standard approaches to gross assessment and margin measurement require further research with increasing use of lung-sparing resections.

Article · Oct 2016 · Archives of pathology & laboratory medicine

Article: Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review

[Show abstract] [Hide abstract] ABSTRACT: Mixed adenoneuroendocrine carcinomas (MANECs) are composite neoplasms with areas of adenocarcinoma or squamous cell carcinoma intermingled with neuroendocrine carcinoma or neuroendocrine tumor, each composing at least 30% of the neoplasm. MANECs are very infrequent overall, and they are more commonly diagnosed in the appendix, colon, and stomach. Biliary MANECs are particularly rare, and their histogenesis is debated because neuroendocrine cells are seldom identified in the normal biliary tract. They can show one of the 3 different architectural patterns described in Lewin's original classification: collision tumors, combined lesions, or amphicrine neoplasms. The neuroendocrine component is usually of a high grade, with small or large cell cytomorphology, whereas the adenocarcinoma component is either an intestinal or biliary type. Clinical presentation is characterized by locally advanced disease at the time of initial diagnosis. Recent studies suggest that treatment should be guided by the most aggressive histologic component.

Article · Oct 2016 · Archives of pathology & laboratory medicine

Article: Physician Satisfaction With Clinical Laboratory Services: A College of American Pathologists Q-Probes Study of 81 Institutions

[Show abstract] [Hide abstract] ABSTRACT: Context: -Assessment of customer satisfaction is a vital component of the laboratory quality improvement program. Objective: -To survey the level of physician satisfaction with hospital clinical laboratory services. Design: -Participating institutions provided demographic information and survey results of physician satisfaction, with specific features of clinical laboratory services individually rated on a scale of 5 (excellent) to 1 (poor). Results: -Eighty-one institutions submitted 2425 surveys. The median overall satisfaction score was 4.2 (10th percentile, 3.6; 90th percentile, 4.6). Of the 16 surveyed areas receiving the highest percentage of excellent/good ratings (combined scores of 4 and 5), quality of results was highest along with test menu adequacy, staff courtesy, and overall satisfaction. Of the 4 categories receiving the lowest percentage values of excellent/good ratings, 3 were related to turnaround time for inpatient "STAT" (tests performed immediately), outpatient STAT, and esoteric tests. The fourth was a new category presented in this survey: ease of electronic order entry. Here, 11.4% (241 of 2121) of physicians assigned below-average (2) or poor (1) scores. The 5 categories deemed most important to physicians included quality of results, turnaround times for inpatient STAT, routine, and outpatient STAT tests, and clinical report format. Overall satisfaction as measured by physician willingness to recommend their laboratory to another physician remains high at 94.5% (2160 of 2286 respondents). Conclusions: -There is a continued trend of high physician satisfaction and loyalty with clinical laboratory services. Physician dissatisfaction with ease of electronic order entry represents a new challenge. Test turnaround times are persistent areas of dissatisfaction, representing areas for improvement.

Article · Oct 2016 · Archives of pathology & laboratory medicine

Article: Atypical Apocrine Adenosis: Diagnostic Challenges and Pitfalls

[Show abstract] [Hide abstract] ABSTRACT: Apocrine change in the breast is an extremely common finding. In most cases, the benign or malignant nature of the lesion is easily recognized. Apocrine adenosis is used to describe sclerosing adenosis with apocrine change. The term apocrine atypia is used when there is significant cytologic atypia in apocrine cells, characterized by a 3-fold nuclear enlargement, prominent/multiple nucleoli, and hyperchromasia. Atypical apocrine adenosis is diagnosed when apocrine adenosis and apocrine atypia are superimposed. However, there are no definite criteria to distinguish atypical apocrine adenosis from apocrine ductal carcinoma in situ. Immunohistochemical markers can be confounding and may lead to erroneous diagnoses. Atypical apocrine features in sclerosing lesions may be misinterpreted as invasive carcinoma if the underlying lesion is not recognized. In the absence of definite features of malignancy, the diagnosis of apocrine ductal carcinoma in situ may be extremely difficult. In the present article, we review atypical apocrine adenosis focusing on diagnostic challenges and their implications on clinical management.

Article · Oct 2016 · Archives of pathology & laboratory medicine

Article: Cytologic and Immunohistochemical Evaluation of Low-Grade Spindle Cell Lesions of the Gastrointestinal Tract

[Show abstract] [Hide abstract] ABSTRACT: Spindle cell lesions of the gastrointestinal tract are relatively uncommon compared with the frequency of their epithelial counterparts. Although gastrointestinal stromal tumors and leiomyomas are the most commonly encountered spindle cell lesions in the stomach and esophagus, respectively, there are other less common diagnostic entities that should be considered for accurate diagnoses as well as appropriate patient treatment and clinical follow-up. Given the morphologic overlap of low-grade spindle cell lesions on cytologic preparations, ancillary studies play a key role in differentiating these lesions from one another.

Article · Oct 2016 · Archives of pathology & laboratory medicine

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June 2010 - Pathology - Laboratory Medicine

June 2010 Pathology & Laboratory Medicine News Items Announcements:
  • Susan Winandy, Ph.D. First Bucher Assistant Professor of Pathology and Laboratory Medicine

The Department of Pathology and Laboratory Medicine is pleased to announce Susan Winandy, Ph.D. as the first Nancy L. R. Bucher Assistant Professor. Dr. Winandy obtained a Bachelor’s of Science degree from the University of Connecticut and a Ph.D. in Biology from the Massachusetts Institute of Technology. Following a post-doctoral fellowship at the Massachusetts General Hospital/Harvard Medical school she assumed a position as an Assistant Professor in the Department of Microbiology – Immunology at the Northwestern University Feinberg School of Medicine. Dr. Winandy has been active in teaching and has served on several thesis committees as well as being an advisor to several students. Her teaching excellence was recognized by the receipt of the Outstanding Teacher for lectures to medical students in the Immunology section. Dr. Winandy’s research investigates how the molecule Ikaros regulates the immune response. Her work has appeared in top tier journals such as the Journal of Immunology, Journal of Experimental Medicine, and the Journal of Biological Chemistry. More than two dozen peer-reviewed manuscripts have been published by Dr. Winandy in addition to several editorials and book chapters. She has served on study sections for the National Institutes of Health and currently is an Associate Editor for the Journal of Immunology.

The Nancy L.R. Bucher Assistant Professorship in Pathology was named for Nancy Bucher, M.D. Research Professor of Pathology and Laboratory Medicine at Boston University School of Medicine. Dr. Bucher enjoys an international reputation for her pioneering research on liver regeneration and the growth of cancer cells. She joined the Department 26 years ago and continues to serve as a distinguished member of the faculty. This named Professorship appropriately acknowledges her long-standing contributions to the research mission of the Department. Established with anonymous contributions, the Nancy L. R. Bucher Assistant Professorship Fund in Pathology is a permanently endowed fund, the income of which provides salary and research resources to a junior faculty member for three to five years. The fund also benefits from the generous challenge grant to establish endowed positions throughout the University. The challenge grant was given by former BU Board of Trustees Chair Alan Leventhal and his wife, Sherry, who is Vice Chair of the BUSM Dean’s Advisory Board.

“Professorships are important to the mission of the School of Medicine because they support the research work of biomedical scientists,” said Dean Karen Antman. “They offer BUSM the opportunity to attract highly distinguished researchers.”

  • Dr Chris Andry was recently notified that he is a recipient of a Strategic International Partner Fellowship at the Institute for Advanced Studies, Warwick University, UK. Dr Andry will travel to Warwick to work with a colleague, Dr Rodger Charlton on two areas of mutual interest “Cultural Competency and Care of the Deceased Patient and their Family” and “The Role of the Decedent Affairs Office in Operational Improvement at Boston Medical Center”.

There exist similarities and extreme differences between the USA and the UK regarding management of deceased patients, which makes this field of study particularly interesting. Understanding decisions about death, bereavement and burial, in the context of cultural preferences, is just one example of an opportunity for research that would benefit physicians and health care workers in many countries.
Dr Andry plans to present on behalf of the Decedent Affairs Office Team (Chris Kiriakos and the Off Shift Nurse Managers) that the role of the DAO at Boston Medical Center is to always ensure that whatever processes govern a patient’s care after death, they must always be performed with dignity and with the best interests of the patient and their family at heart.

  • Congratulations to this year’s recipients of Henry I. Russek Student Achievement Awards in the Department of Pathology:
    • First Prize- Madhumita Jagannathan – Congratulations!
  • Second Prize- Jillian Richmond – Bravo!

    As described by the founder of the Student Achievement Awards program, Dr. Shelley Russek, Professor of Pharmacology at the Medical School, “…[T]hese Achievement Awards go to students who have distinguished themselves not only as gifted researchers in their mentor’s laboratory but also as dedicated members of their department and/or program.” More information about the Russek Awards can be found at this link <http://www.bumc.bu.edu/gms/achievement-day-2010/>

    • June is PhD Qualifying Exams Month! This year June 2nd will be the written part of the exam and June 8th and 9th the oral portion will take place. There are six students who will be taking their qualifying exams this season: Dominic Beal, Atsushi Ebata, Ed Hartsough, Tricia Kao, Ritu Moitra and Sri Srinivasan. The faculty working with this group of candidates is: Drs. Berse, Burke, Murnane, Rahimi, Remick, and Slack. Good Luck to all! Thank you to Dr. Bohdana Burke for all of her hard work coordinating!
    • Martin Steffen, PhD will have a feature article profiling his lab’s gene function validation in The Scientist, with an embargo date on May 27. Reporter Jef Akst recently interviewed Martin and his team for a feature news story. A link to this article will be provided next New News issue.
    • The Kurosawa Lab welcomes Ms. Ishbel “Bella” Heru as a part-time research technician. Bella is a graduate of BU and comes to us most recently from Brown University with experience in a crystallography lab.
    • Congratulations to Besam Khidhir, MD/PhD Candidate who successfully Defended his thesis “Radiologic Localization of Pathologic Lesions Using Image Registration” on May 24th; Besam will be returning to Medical School in June
    • Congratulations to Lou Vaickus, MD/PhD Candidate who successfully Defended his thesis “Cockroach Allergens Induce a Biphasic Asthmatic Response” on May 25th; Lou will be returning to Medical School in June
    • We are inviting all graduate students to join our New Graduate Student Discussion Board, open to all current and inquiring students about our program. The expectation is that students will pose questions and we will answer (in a timely manner). This will allow, especially inquiring students, to get immediate answers to questions that may not be readily available on our web page or that is unique to him/her. We encourage your input since you are in the trenches and can probably answer many of these questions best. We are also welcoming any BUSM or Boston, “Did you know…” items. Please send to dekiley@bu.edu. Feedback about how the Discussion Board is going will be appreciated. Here is the link :
    • Graduation Photos

    Catherine Cory, MA and Dr. Daniel Remick, Chair Pathology and Laboratory Medicine



Archives Of Pathology Laboratory Medicine Online Updated 2016 - Lek Lek

114 Search results Archives Of Pathology Laboratory Medicine Online

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