Dissertation for the degree of Doctor of Science in Technology to be presented with due permission of the Faculty of Information and Natural Sciences for public examination and debate in Auditorium AS1 at Helsinki University of Technology (Espoo, Finland) on the 29 th of May, 2008, at 12 noon.
Overview in PDF format (ISBN 978-951-22-9372-8) [2975 KB]
Dissertation is also available in print (ISBN 978-951-22-9371-1)
In this Thesis the synthesis of various Newkome-type polyamine dendrons and their DNA binding properties is presented. These cationic dendrons bind DNA with extremely high affinity through multivalent ionic interactions. Dendrons with o -nitrobenzyl linked surface groups can be cleaved from the dendron framework by optical irradiation resulting in rapid release of the covalently bound surface groups and non-covalently bound DNA, due to dendron degradation and charge switching multivalency. N -maleimido cored dendrons can be attached onto protein surfaces in site-specific manner to yield exactly defined one-to-one protein-polymer conjugates, where the number of dendrons and their attachment site on the protein surface is precisely known. The resulting protein-dendron conjugates bind DNA with high affinity. Further studies in gene transfection, cytotoxicity and self-assembly establish relevance in gene therapy and surface patterning.
This thesis consists of an overview and of the following 5 publications:
Keywords: self-assembly, dendrimers, dendron, DNA, protein
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
© 2008 Helsinki University of Technology
Last update 2011-05-26
International Standard Book Number (ISBN) assigned to a monographic publication by designated agencies in each country participating in the program. The field may include terms of availability and canceled or invalid ISBNs, such as ISBNs with invalid check digits or that are not applicable to the item being cataloged. It may be repeated for multiple numbers associated with the item (e.g. ISBNs for the hard bound and paperback manifestations; ISBNs for a set as a whole and for the individual parts in the set).
Each field contains all the information relevant to one ISBN, or if no ISBN exists, relevant to the item being cataloged.GUIDELINES FOR APPLYING CONTENT DESIGNATORS ■ INDICATORS
Qualifying Information - In displays, qualifying information may be enclosed in parentheses.
ISBN Structure - ISBN is an agency-assigned data element. ISBNs are assigned to monographic publications by designated agencies in each country participating in the program. An ISBN consists of ten or thirteen digits. The 10-digit ISBN comprises four groups separated by hyphens. (The tenth digit is a check digit used as a computer validity check; it consists of a number between 0 and 9 or an uppercase X (for the arabic numeral 10). The 13-digit ISBN comprises of five elements. Element one consists of a 3-digit EAN prefix that identifies the book industry. Element two identifies the country or language agency. Element three identifies the publisher prefix. Element four identifies the title or specific edition of a publication. Element five contains a check digit.
Procedures for validation of the ISBN by calculating the check digit and hyphenating instructions are in Information and Documentation - International Standard Book Numbering (ISBN) (ISO 2108).
Classes of ISBNs - ISBNs may be valid for the item being cataloged, or canceled, structurally invalid, or application invalid. The following conventions may be followed to select the appropriate subfield for an ISBN.
Valid ISBN: - Valid ISBN is one in which the length, structure, and check digit are correct, and the ISBN is applicable to the item being cataloged. The validity of an ISBN to a particular bibliographic item is usually related to the treatment given it by the cataloging agency in terms of the number of records involved. If a single record represents more than one manifestation, e.g. hard back and paperback, both ISBNs are valid. If a single record represents a multipart monograph, ISBNs for the set as a whole and those for individual volumes are valid. If a single record describes the main part and supplemental parts of a bibliographic item, all ISBNs for the main and the supplemental material are valid. In cases of multiple valid ISBNs in one record, appropriate qualifiers to differentiate the ISBNs are usually included. Note that during the transition from a 10-digit ISBN to a 13-digit one (2005-2007), some bibliographic agencies include both a 13-digit number and a 10-digit one for the same item in repeated 020 fields. In such cases, parenthetical qualification is not used to differentiate between the 10-digit and 13-digit ISBNs.
Canceled ISBN: - ISBN is considered to be canceled when a publisher designates it as such.
Structurally invalid ISBN: - ISBN is considered to be structurally invalid when its length or structure is incorrect or its check digit does not agree with the formula for calculating it.
Application invalid ISBN: - ISBN is considered to be application invalid for a particular record when it appears on the bibliographic item, but it is known, through research or other means, that the same number is also assigned to a different resource.
ISBN may also be considered to be application invalid if it is not directly applicable to the bibliographic item represented by a particular record. Application invalidity is usually related to the cataloging treatment employed by a particular agency in terms of the number of records involved. For example, if there is a record for a multivolume set as well as separate records for each of the volumes in the set, the ISBN for the set is considered application invalid on the records for the volumes. Only the ISBN applicable to the entity represented by a particular record is considered valid on that record.
Punctuation - Field 020 does not end with a period.
Law School Bound™ And Mastering The LSAT® Ordering Information:
Mastering The LSAT® –
ISBN: 0-9696290-3-6 – 304 pages - $31.95 Cdn
You may order either Law School Bound or Mastering The LSAT or both by:
Box 19602, Manulife P.O.
55 Bloor St. W.
Orders From Bookstores: We offer the usual terms – don’t forget the PO number.
Orders From Individuals: Orders that do not come from bookstores must be prepaid by VISA. Mastercard or Money Order payable to “Richardson Press”. The total price for individual orders which include the book(s), GST and mailing by Canada Post are as follows:
- Law School Bound™ - $60 if mailed to Canada - $70 if to the U.S.
- Mastering The LSAT® - $40 if mailed to Canada - $50 if to the U.S.
- Law School Bound™ and Mastering The LSAT® (Specially discounted price) - $80 if mailed to Canada - $90 if to the U.S.
Orders from individuals (which must be prepaid) must include your name, address, phone number, email address, credit card number and expiry date. Be clear on which book or books you are ordering.
Please note also that you may order the books from Indigo and Amazon. They are also available inside these stores and at most university bookstores.
In the book world, we’ve come to take International Standard Book Number (ISBN) - that 13 digit number found on the copyright page or back of a book - for granted. We may not need to understand how the number is made up, but we know it’s a number that identifies a book and that it somehow makes ordering and sales more accurate and efficient.
In the 1960s publishers wanted to improve their efficiency and profitability, but how could they introduce automated order processing and inventory control systems, when the products could not be consistently and reliably identified? Giving numbers to books wasn’t new – many publishers did that – but the idea of a standard book number that could be used on all computers and which could uniquely identify a publication was startling.
The idea for the system started in the UK prompted by WH Smith announcing in 1965 that they wanted to move to a computerised warehouse within two years. There were a number of reports and working parties and eventually a 9-digit number, including a final “check digit” to validate the whole number, was proposed. The UK was the first to adopt this “Standard” Book Number and the first registration agency was operated on behalf of the trade by J Whitaker and Sons Ltd. - its success was immediate. Soon RR Bowker in US, and national libraries and bibliographic services in Canada, Australia, Denmark, Sweden and The Netherlands also wanted to join the system. So, to accommodate this expansion to other countries, the number was increased to 10 digits and became an International Standard under the auspices of International Organization for Standardization (ISO) in 1970. Following later developments, the ISBN has been a 13-digit number since 1 January 2007.
Books are a unique industry – there are many new product lines every day, but also older ones remain very much in demand. You can order and read books that were originally written many hundreds of years ago as well as the very latest releases. Books also come in many types and formats – hardbacks, paperbacks, pop-up books, audio-books, and digital books for e-readers, tablets and smartphones, etc. An ISBN is used to identify a particular book from a specific publisher that appears in any form, and is available to the public.
Today, fifty years on, there are more than 150 national and regional ISBN agencies providing ISBNs to publishers in more than 200 countries. We live in a world where information about books is not only based on walking into a bookshop but also readily accessible through internet searches. Websites can display all the information about a book from basics such as the author’s name, the title and price, through to an image of the cover, the number of pages, even links to reviews. In most cases, it is the ISBN that is the glue that binds all this information into a single, searchable record. Without ISBN, it is unlikely that there would be bar codes on books. There wouldn’t be systems such as Nielsen BookNet TeleOrdering which automatically routes orders to the correct supplier thereby saving the bookseller time and effort. Sales data would be less granular; product databases would be less efficiently compiled and contain a lot less information. Quite simply, there would probably be chaos.
On 13 October 2015, the International ISBN Agency will hold a reception to celebrate 50 years of standard book numbering at EDItEUR’s 37th International Supply Chain Seminar in Frankfurt in Room Concord, Halle 4.C at Frankfurt Messe.
Yes, the content of such a publication could be identified by ISBN in this format.
Compact discs (CDs)
CDs are only eligible for ISBNs if they are spoken word or instructional. Music or performance CDs are never assigned ISBNs. Meditation CDs that combine music and spoken word are not eligible for ISBNs. If the CD is eligible for an ISBN, the ISBN is placed near the copyright line on the packaging. The UPC (now called the GS1) bar code is the appropriate product identification standard for a music CD.
Chapters, paragraphs, charts, etc.
Chapters, paragraphs, charts and other sections of published text are eligible for their own ISBNs if a publisher is selling them separately.
Coffee mugs and other utensils
Greeting cards are not assigned ISBNs unless required by the retailer. If assigned, they are assigned by price point rather than design. For example, if several different designs are all sold for the same price, only one ISBN is used.
Yes. Historical documents archived in a library or museum are part of the bibliographic record of interest to researchers. They meet the criteria for discoverability and reporting that is part of the ISBN system.
Journals and diaries
Journals and diaries can be assigned ISBNs when required by retailers.
Yes, such reference works are routinely tracked by revenue strands (individual vs. library subscription reporting) by publishers.
by Christian Nagel
Windows Presentation Foundation (WPF) is one of the three major extensions of .NET Framework 3.0. WPF is a new library to create the UI for smart client applications. While the Windows Forms controls are based on native Windows controls that make use of Window handles that are based on screen pixels, WPF is based on DirectX. The application is no longer using Window handles, it is easy to resize the UI, and support for sound and video is included.
Windows Forms 2.0 data binding has a lot of improvements compared to 1.0. WPF data binding takes another huge step forward. This article gives you a good start in data binding with WPF and discusses these Simple Object Binding, Object Data Provider, and List Binding. In Chapter 31, "Windows Presentation Foundation," of the new book, Professional C# 2005 with .NET 3.0(Wrox, 2007, ISBN: 978-0-470-12472-7), we also discuss Binding with XAML and Binding to XML.Overview
With WPF data binding, the target can be any dependency property of a WPF element, and every property of a CLR object can be the source. Because a WPF element is implemented as a .NET class, every WPF element can also be the source. See Figure 1 for the connection between the source and the target. The Binding object defines the connection.
Binding supports several binding modes between the target and source. Binding can be one-way where the source information goes to the target, but if the user changes information in the user interface, the source does not get updated. For updates to the source two-way binding is required.
The following table shows the binding modes and their requirements.
The ISBN number provides a standard way to identify your book, especially for bookstores and libraries. You will need an ISBN number and bar code if you want to sell your book in any kind of bookstore, either bricks and mortar or on the internet.
The ISBN number ties into a catalog of all (registered) books in print. This catalog lists the publisher, access and purchasing information, and descriptive data about each book.
As a grammatical comment, "ISBN number" is redundant; "ISBN" means "International Standard Book Number", so "ISBN number" is "International Standard Book Number number". But it's common to say number anyway.FAQs for Self-Publishers (Provided by Bowker)
What is an ISBN?
ISBN means International Standard Book Number. An ISBN is a number, used like a serial number so that bookstores can accurately order books. An ISBN is not a bar code.
Why do I need an ISBN?
If you are selling your book on your own, you are not required to have an ISBN. If you want to sell your book in bookstores, place it with distributors and wholesalers, and put it in libraries, you are required to have an ISBN on your book.
Can a self-publisher obtain an ISBN?
Yes, a self-publisher is a publisher: one who is undertaking the financial risk to bring a book to market and coordinating everything involved: advertising, marketing, printing, order fulfillment, etc.
How does the process work?
First, a publisher applies for an ISBN. The ISBN Agency emails the ISBN to the publisher. The ISBN is placed on the copyright page and is encoded on a bar code, which is placed on the back cover of the book. Then, when the book is about to be sold, the publisher registers the title in Books in Print at www.bowkerlink.com.
What happens if another publisher wants to publish my book?
The new publisher will put their ISBN on your book and the ISBN you were using will no longer be on the book or used at all. An ISBN identifies both the title and the publisher from which it can be ordered.
Can I reuse my ISBN?
No, once an ISBN is assigned to a book, the ISBN cannot be reused. If the content of the book changes, a new ISBN must be used. If the title of the book is changed after its publication, then a new ISBN must be used.
Can I sell or give my ISBN to someone else?
No, you cannot sell or give an ISBN to anyone. ISBNs cannot be transferred. The US ISBN Agency is the only one who can assign ISBNs.
Why should I register my title in Books in Print?
Books in Print is the main directory that bookstores and libraries use to locate books they want to order for their customers. If you want your book to be found and ordered, you should register it in Books in Print.
How do I register my title in Books in Print?
Publishers register their titles in Books in Print at www.bowkerlink.com. Please wait to receive your ISBN before going to Bowkerlink and registering as a new user.
Do you also assign Library of Congress catalogue numbers and handle copyright?
The U.S. ISBN Agency does not assign Library of Congress catalog numbers. The Library of Congress does this. The ISBN Agency is not a part of the Library of Congress. You can reach the Library of Congress at www.loc.gov. Copyright is also handled by the Library of Congress.
Do I need a bar code?
You will need a bar code if you are going to sell your book in stores. There are several different bar code systems in the United States. The kind of bar code used in bookstores is called the EAN 13 bar code. You can purchase an EAN 13 bar code at the time you order your ISBN or you can get one afterward from a bar code supplier, or www.bowkerbarcode.com.
What products are eligible for ISBNs?
ISBNs may be assigned to books and certain other items commonly found in bookstores. Non-book items eligible for ISBNs include ebooks, audiobooks, calendars, bookmarks, software, greeting cards, and instructional and documentary DVDs and videos. ISBNs may never be assigned to music CDs, articles of clothing, foods, medicine, or stuffed animals, among other items.
What is a distributor? What is a wholesaler? What is a retailer?
A distributor is a business that has a signed exclusive contract with a publisher to sell their books. The distributor warehouses the books, fulfills orders, and issues invoices. A wholesaler buys and sells books without an exclusive agreement with the publisher. The wholesaler consolidates orders to retailers. A retailer sells books to the public. A retailer can be a physical store or it can be online.
Signature Book Printing has been a Book Printer of choice for the past 25 years. We have been on the web since 1997. From the beginning, we have focused not only on Book Printing but also on smooth, easy customer service, excellent quality, and very competitive prices . We have broadened our Book Printing offerings significantly from the beginning. Check out Signature Book Printing as your Book Printer . As a Book Printer . we have earned the confidence and recommendations of a wide variety of customers nationwide to support their Publishing . Our capabilities include Hard Cover Book Printing . Full Color Book Printing . Case Bound Book Printing . Perfect Bound Book Printing . Smythe Sewn Binding . Soft Cover Book Printing . and Web Book Printing for longer runs.
Dyn 1 - ver 22.214.171.124 � 1997 - 2015 Signature Book Printing, Inc. Updated 10/28/16 07:11
The Library of Congress assigns a catalog control number (PCN) for every submission to the Library’s permanent collection. The service provides convenient filing information for U.S. libraries. While submission to the Library is not required, we feel it is an essential part of publishing your book, so we include it at no charge to you.
This service is included in all of our publishing packages, provided that the publication date is set at least two months after final manuscript submission. This window allows processing time for the Library and inclusion of their data in the book’s interior. We will handle the paperwork beforehand and submit the required copies of your book once it’s published.
The Library of Congress does not provide catalog numbers for books under 50 pages unless they are Children’s books. The Library also reserves the right to refuse cataloging.
As an optional service, we can prepare Catalog in Publication (CIP) data for your book, in addition to the PCN. CIP data is recommended for books that may be widely acquired by libraries and will help to facilitate sales to libraries.
You already own the copyright at the moment you create a work of art. However, to ensure complete protection of your book under US copyright law, it is advisable to register your book with the United States Copyright Office. Once registered, your book’s copyright is fully protected for your lifetime plus 70 years.
Registration with the US Copyright Office is not required and most self-publishing services charge additional fees for it. However, we feel that this registration is an essential part of publishing your book, so we include this service at no additional charge in all of our programs.
We’ll submit the required copies of your book and all the necessary paperwork. Notice of copyright will be sent directly to you approximately six months to one year after completion of the publication process.
Cataloging-in-Publication (CIP) data is the block of information found at the bottom of some copyright pages. The information provided by the CIP allows librarians to quickly add the book to their database and get the book into circulation faster. If your book has the potential to be a popular library acquisition, we recommend adding CIP data to your book.
Using the same resources as the Library of Congress, our catalogers assign Publisher’s Cataloging-in-Publication (PCIP) information to your materials including Library of Congress subject headings and LC and Dewey classification numbers, making your product stand out to librarians. The results: Faster turn-around time for the publisher, the library, and the end-user.
All PCIPs we create are added to two widely used bibliographic utilities used by librarians, OCLC’s WorldCat and SkyRiver. These services provide the PCIP data to libraries digitally to take more burden off librarians.
During the publishing process, we will discuss the ISBN and the processes available to obtain it for identifying your title.For more information:
ISBN (International Standard Book Number)is a worldwide identification system that has been in use since the late 1960's. There is a different ISBN number for each edition and binding of every book. To obtain an ISBN number application electronically, visit www.isbn.org or contact the U.S. ISBN Agency:
U.S. ISBN Agency
630 Central Avenue
New Providence, NJ 07974
This application link provided above is for U.S. ISBN Publisher Prefix and is not for foreign publishers use (foreign publishers must apply to their own national agencies to obtain ISBN numbers). Complete the form and return to the ISBN Agency with processing fee (approximately $200, subject to change). Allow 20 days processing time. You may request 72-hour turnaround for an additional charge. Publishers should start this process before their publication is sent to the printer. The ISBN Agency will issue you 10 ISBN numbers (more if requested). Select one for use on your current project and reserve the balance for future projects.13 Digit ISBN Explained:
Digits 1-3: "979" Prefix
Digit 4: registration group identifies country or region
Digits 5-7: identifies the publisher
Digits 8-12: identifies the title and edition (hard or soft cover) of the book
Digit 13: check digit; this is a mathematical function to check the accuracy of the other digits
Your ISBN should be printed on the copyright page and the lower right-hand corner of the outside back cover and back jacket, or below the bar code. Dust jackets should carry the ISBN on the upper edge of the left-hand jacket flap.
ISSN'S (International Standard Serial Number) are issued for serial publications, magazines and directories. Serials are print or non-print publications issued in parts, usually bearing issue numbers and/or dates. A serial is expected to continue indefinitely. Serials include magazines, newspapers, annuals (such as reports, yearbooks, and directories), journals, memoirs, proceedings, transactions of societies and monographic series. An ISSN is eight digits long and always displayed this way: ISSN 1234-5679.
ISSNs’ first seven digits serve as the title number and the eighth is a check digit, which provides an efficient means for discovering transcription errors. The system used for calculating the check digit sometimes requires a check number of 10, in which case, to prevent a nine-digit ISSN, the Roman numeral "X" is substituted. For each serial with an ISSN there is a corresponding "key title" – a commonly acceptable form of the title established at the time of ISSN assignment. The title provides a benchmark that serves to regulate the assignment of ISSN, so if the title of a serial changes, a new ISSN must be assigned.
The coordination of the ISSN is international, with registration initiated at the national level where serials are published. The National Serials Data Program (NSDP) within the Library of Congress is the U.S. Center of the ISSN Network. The ISSN International Centre located in Paris coordinates the network. NSDP is responsible for registering and providing ISSN for serials published in the United States and for promoting use of the ISSN.Advantages of ISSN Use:
The ISSN should be as basic a part of a serial as the title. The advantages of using it are abundant and the more the number is used the more benefits will accrue.
Call the Library of Congress for National Serials Data Program at. 202-707-6452 .Library of Congress (LC) Catalog Card Number
The Library of Congress Catalog Number is essential for publishers if they sell to the library market. To obtain a Library of Congress Catalog Number, visit their website at pcn.loc.gov/pcn .
CIP Data Block (Catalog In Publication Data Block)
Every book with a library market should have a Library of Congress CIP Data Block on its copyright page. Publishers can create their own
CIP Data Block with the help of a local librarian:
The following information will have to be taken to the library in order for the librarian to help:
Your data block will be listed as Publisher's Cataloging in Publication Data, not Library of Congress Cataloging in Publication Data. CIP Data Block information should be included on the title page.Copyright Registration
Contact the Copyright Office, Library of Congress in Washington, D.C. at 202-707-9100. Ask for Form TX (application for copyright of books). Complete the form and return with it a $20 check (subject to change) made payable to Register of Copyrights along with two copies of your finished publication (no galleys) to the Copyright Office within two weeks of receiving books from printer.EAN Bar Code
Every book sold in chain bookstores should have an EAN Bar Code printed on the lower right corner of the back cover. Thomson-Shore can create a barcode for you if you supply us with your ISBN and suggested retail price for your book.Bar Code Graphics
Thomson-Shore can create a barcode for you if you supply us with your ISBN and the suggested retail price for your book.ISBN Information Links
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